Treatment of heavily calcified popliteal artery with Rotational Atherectomy System and DCB

Description of lesion

Calcified popliteal artery

Description of procedure

Treatment of heavily calcified popliteal artery with Phoenix Rotational Atherectomy System and Stellarex DCB
 

Learning objectives

Understand how vessel preparation with Phoenix atherectomy can

• Effectively modify heavy calcification encountered in PAD intervention
• Increase acute success of DCB angioplasty (and theoretically long term success)
• Facilitate a leave nothing behind strategy for even the most complex lesions

Understand how Stellarex DCB can improve the durability of treatment in complex lesions

• Perform in calcium (PEG forms strong ionic bonds with hydroxyl apatite (HAp) (1) the primary component of calcified atherosclerotic lesions, which may limit PTX washout in the presence of calcium PEG may protect PTX, giving it time to be absorbed into vessel when calcium is present
• Ensure high transfer efficiency and effective residency (2)

References

1. Venkatasubbu GD, et al. Surface modification and paclitaxel drug delivery of folic acid modified polyethylene glycol functionalized hydroxyapatite nanoparticles. Powder Technology. 2013;235:437-442.
2. Superimposed PK curves from different datasets: Melder R, EuroPCR 2012, Yazdani, et al. Catheterization and Cardiovascular Interventions 2014;83:132-140. Data on file at Philips.